Laboratory of Dr. Paul Shaw PhD, Department of Anatomy and Neurobiology
Peer Reviewed Papers
Donlea JM, Ramanan, N. Gottschalk L, Silverman, N., Shaw PJ. (In Review) Genetic rescue of functional senescence in synaptic and behavioral plasticity. SLEEP
Vanderheyden, WM, Gerstner JR, Swanson J, Yin JC, Shaw PJ (In Press) Phosphorylation Regulates Sleep and Use-dependent Plasticity in Drosophila. PLoS One
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Thimgan, M.S., Gottschalk, L., Toedebusch, C., McLeland, J., Rechtschaffen, A., Gilliland-Roberts, M., Duntley, S.P., and Shaw, P.J. (2013). Cross-translational studies in human and Drosophila identify markers of sleep loss. PLoS One 8, e61016.
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Shaw, P.J., Tafti, M., and Thorpy, M. eds. (2013). The Genetic Basis of Sleep and Sleep Disorders (New York: Cambridge University Press).
Shaw, P.J., and Duntley, S.P. (2012). Neurological disorders: towards a mechanistic understanding of restless legs syndrome. Curr Biol 22, R485-486.
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Le Glou, E., Seugnet, L., Shaw, P.J., Preat, T., and Goguel, V. (2012). Circadian modulation of consolidated memory retrieval following sleep deprivation in Drosophila. Sleep 35, 1377-1384B
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Donlea J.M., Leahy A., Thimgan M.S., Suzuki Y., Hughson B.N., Sokolowski M.B., Shaw P.J. Foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2613-8. Epub 2012 Jan 30.
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Seugnet L, Suzuki Y, Merlin G, Gottschalk L, Duntley SP and Shaw PJ (2011) Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila. Current Biology, 21:8345-840.
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Donlea JM, Thimgan MS, Suzuki Y, Gottschalk L, Shaw PJ (2011) Inducing sleep by remote control facilitates memory consolidation in Drosophila. Science, 322:1571-1576.
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Thimgan MS, Duntley SP, Shaw PJ (2011) Changes in gene expression with sleep. J. Clin Sleep Med., 7:S26-27.
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Seugnet L, Suzuki Y, Donlea JM, Gottschalk L, and Shaw PJ (2010) Sleep deprivation during early-adult development results in long-lasting learning deficits in adult Drosophila. Sleep, 34:137-146.
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Thimgan MS, Suzuki Y, Seugnet L, Gottschalk L., Shaw PJ (2010) The perilipin homologue,lipd storage droplet 2, regulates sleep homeostasis and prevents learning impairments following sleep loss. PLoS Biol., 8:e1000466.
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Donlea JM, Shaw PJ (2009) Sleeping together using social interactions to understand the role of sleep in plasticity. Adv. Genet., 68:57-81.
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Seugnet L, Suzuki Y, thimgan M, Donlea J, Gimbel SI, et al. (2009) Identifying sleep regulatory genes using a Drosophila model of insomnia. J. Neurosci., 29:7148-7157.
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Donlea JM, Ramanan N, and Shaw PJ (2009) Use-dependent plasticity in clock neurons regulates sleep need in Drosophila. Science 324:105-108.
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Seugnet L, Galvin JE, Suzuki Y, Gottschalk L, Shaw PJ (2009) Persistent short-term memory defects following sleep deprivation in a Drosophila model of Parkinson's Disease. Sleep, 32:984-992.
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Seugnet L, Suzuki Y, Stidd and Shaw PJ (2009) Aversive phototaxic suppression: evaluation of a short-term memory assay in Drosophila. Genes Brain and Behav. 8:377-389.
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Kilduff TS, Lein ES, de la Iglesia H, Sakurai T, Fu Y, and Shaw PJ (2008) New developments in sleep research: molecular genetics, gene expression and systems neurobiology. J. Neuroscience 28:11814-11818.
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Seugnet L, Suzuki Y, Vine L, Gottschalk L, Shaw PJ (2008) D1 receptor activation in the mushroom bodies rescues sleep-loss-induced learning impairments in drosophila. Curr Biol 18:1110-1117.
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Seugnet L, Boero J, Gottschalk L, Duntley SP and Shaw PJ (2006) Identification of a biomarker for sleep drive in flies and human. PNAS, 103:19913-19918.
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Ganguly-Fitzgerald I, Donlea J, Shaw PJ (2006) Waking experience affects sleep need in Drosophila. Science, 313:1775-1781.
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Andretic R and Shaw PJ (2005) Essentials of sleep recordings in Drosophila: moving beyond sleep time. Methods in Enzymology. 393:759-771
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Shaw PJ, Tononi G, Greenspan RJ, Robinson DF (2002) Stress response genes protect against the lethal effects of sleep deprivation in Drosophila melanogaster. Nature, 2002 417:287-91.
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Greenspan RJ, Tononi G, Cirelli C , Shaw PJ (2001) Sleep and the fruit fly. Trends Neurosci., 24:142-5.
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Shaw PJ, Cirelli C, Greenspan RJ and Tononi G (2000) Correlates of sleep and waking in Drosophila Melanogaster. Science, 287:1834-1837.
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Shaw PJ, Cirelli C and Tononi G (1999) Effects of chronic paradoxical sleep deprivation on gene expression in the cerebral cortex of the rat. Sleep, 22 (suppl. #1):113.
Cirelli C, Shaw PJ, Rechtschaffen A and Tononi G (1999) No evidence of brain cell degeneration after long-term sleep deprivation in rats. Brain Res 840:184-93
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Shaw PJ, Bergmann BM and Rechtschaffen A (1998) The effects of paradoxical sleep deprivation on thermoregulation in the rat. Sleep. 21:7-17.
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Shaw PJ, Bergmann BM and Rechtschaffen A (1997) Operant control of ambient temperature during sleep deprivation. Am.J.Physiol. 272:R682-90.
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Bergmann BM, Gilliland MA, Feng P, Russell DR, Shaw PJ, Wright M and Rechtschaffen A (1996) Are physiological effects of sleep deprivation mediated by Bacterial Invasion? Sleep. 19:554-562, 1996.
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Feng P, Shaw PJ, Bergmann BM, Obermeyer W, Tsai LL, Zenko CE and Rechtschaffen A (1995) Sleep Deprivation in the Rat: XX. Differences in wake and sleep temperatures during recovery. Sleep. 18:797-804.
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Hawkins J and Shaw PJ (1992) Self-reported sleep quality in college students: A repeated measures approach. Sleep 15:545-549.
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Hawkins J and Shaw PJ (1991) Sleep satisfaction and intentional self-awakening: An alternative protocol for self report data. Perceptual and Motor Skills 70:1412.
Shaw PJ, Puentes J, Reis C and Hicks RA (1990) REM sleep deprivation fails to increase intraspecies aggression in female rats. Bulletin of the Psychonomic Society.
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Book Chapters
Dissel, S., and Shaw, P.J. (2013). Drosophila model systems for genetic sleep research. In The Genetic Basis of Sleep and Sleep Disorders, P.J. Shaw, M. Tafti and M. Thorpy, eds. (Ney York: Cambridge Press), pp. 152-185.
Perlis M, Shaw PJ, Cano G, and Espie C (2010) Models of Insomnia. In Principles and Practices of Sleep Medicine, Eds. Kryger MH, Dement WC and Roth T. Elsevier
Donlea JM, Seugnet L, and Shaw PJ (2009) Genetics of Sleep in Drosophila Melanogaster.Current Advances in Sleep Biology.
Donlea JM and Shaw PJ. (2008) What flies can tell us about mammalian sleep and circadian rhythms. Encyclopedia of Neuroscience, (Elsevier Ltd).
Shaw P.J. (2005) Effects of sleep deprivation on body temperature regulation. In: Kushida CA (ed): Sleep deprivation. New York, Marcel Dekker, pp. 319-338.