Our laboratory utilizes a variety of techniques spanning from human molecular genetics and informatics to mouse behavioral neuroscience and neuroanatomy. We develop and employ mouse models of psychiatric disorder, particularly those that mimic genetic variations we’ve identified from human patient populations, with the goal of trying to understand the cellular and molecular underpinnings of these disorders. We are particularly focused on the neurodevelopmental disorder of autism.
Research Publications
Dougherty JD, Schmidt EF, Nakajima M, Heintz N (2010 Jul). Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells. Nucleic Acids Res. 38 (13): 4218-30. Full Article >
Doyle JP, Dougherty JD, Heiman M, Schmidt EF, Stevens TR, Ma G, Bupp S, Shrestha P, Shah RD, Doughty ML, Gong S, Greengard P, Heintz N (2008 Nov 14). Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell. 135 (4): 749-62. Full Article >
Nakano I, Dougherty JD, Kim K, Klement I, Geschwind DH, Kornblum HI (2007 Aug). Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells. 25 (8): 1975-84. Full Article >
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H (2006 Jan 3). PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 103 (1): 111-6. Full Article >
Dougherty JD, Garcia AD, Nakano I, Livingstone M, Norris B, Polakiewicz R, Wexler EM, Sofroniew MV, Kornblum HI, Geschwind DH (2005 Nov 16). PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. J Neurosci. 25 (46): 10773-85. Full Article >
Contact Info
Joseph Dougherty, Ph.D.
Office Phone: 314-286-0752
Lab Phone: 314-362-6181
Fax: 314-362-7855
dougherty@WUSTL.EDU
