In 1910, Joseph
Erlanger was invited by Washington
University to head the Department of Physiology in
the newly reorganized School of Medicine. Herbert
Gasser joined the department shortly after and he
and Erlanger began a collaboration in studies on fundamental
properties of nerve. Erlanger and Gasser
built and assembled the requisite equipment for stimulation
and recording. With it they investigated the
characteristics of conduction nerve axons.
Together with George Bishop, who subsequently joined
in the work, they determined the speed of conduction
in nerve fibers and its relation to axonal diameter,
the independence of action potentials, in individual
nerve fibers, the time course of the individual action
potentials, the refractory period after an action
potential and a host of other properties which are
fundamental to our understanding of nerve physiology.
In 1921 Gasser was made Head of the Department
of Pharmacology at Washington University. He
continued collaborating with Erlanger and Bishop.
They were very successful in reconstructing
the compound action potential from the fiber diameter
spectrum, their values for action potential size and
duration, and assuming a linear relation between axon
diameter and conduction velocity. In 1944,
Erlanger and Gasser were awarded the Nobel Prize in
Physiology or Medicine for these studies.
In
1932, Gasser moved to New York as chairman of the
Department of Physiology at Cornell Medical
School. Three years later, he was appointed Director of the Rockefeller Institute for Medical
Research, a post he held until his retirement in 1953.
He then returned to the laboratory and again
turned his attention to peripheral nerve. During
these years, he made important discoveries on unmyelinated
nerve axons. He died in 1963. Erlanger remained
as Head of Physiology at Washington University until
1946. He continued working on problems of peripheral
nerve including excitation, effects of polarization
and repetitive firing of axons. In addition
to research, he contributed much as an administrator
and teacher. A founding member of the Executive
Faculty, he played a large role in the building of
the modern Washington University School of Medicine.
He died in 1965.
Past
Erlanger-Gasser Speakers
1990 |
Dr.
Stanley Cohen |
1991 |
Dr.
George E. Palade |
1992 |
Dr.
Andrew Huxley |
1992 |
Dr.
Bert Sakmann |
1994 |
Dr.
Edwin G. Krebs, M.D. |
1995 |
Dr.
Gunter Blobel |
1996 |
Dr.
Alfred G. Gilman |
1998 |
Dr.
Gerald D. Fischbach |
2000 |
Dr.
Floyd E. Bloom |
2002 |
Dr.
Clay M. Armstrong |
2003 |
Dr.
Wolfhard Almers |
2004 |
Dr.
Anton J. Berns |
2006 |
Dr.
Thomas D. Pollard |
|