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The Erlanger-Gasser Lecture                                                      

In 1910, Joseph Erlanger was invited by Washington University to head the Department of Physiology in the newly reorganized School of Medicine.   Herbert Gasser joined the department shortly after and he and Erlanger began a collaboration in studies on fundamental properties of nerve.    Erlanger and Gasser built and assembled the requisite equipment for stimulation and recording.   With it they investigated the characteristics of conduction nerve axons.   Together with George Bishop, who subsequently joined in the work, they determined the speed of conduction in nerve fibers and its relation to axonal diameter, the independence of action potentials, in individual nerve fibers, the time course of the individual action potentials, the refractory period after an action potential and a host of other properties which are fundamental to our understanding of nerve physiology.   In 1921 Gasser was made Head of the Department of Pharmacology at Washington University.   He continued collaborating with Erlanger and Bishop.   They were very successful in reconstructing the compound action potential from the fiber diameter spectrum, their values for action potential size and duration, and assuming a linear relation between axon diameter and conduction velocity.   In 1944, Erlanger and Gasser were awarded the Nobel Prize in Physiology or Medicine for these studies.

 

In 1932, Gasser moved to New York as chairman of the Department of  Physiology at Cornell Medical School.   Three years later, he was appointed  Director of the Rockefeller Institute for Medical Research, a post he held until his retirement in 1953.   He then returned to the laboratory and again turned his attention to peripheral nerve.   During these years, he made important discoveries on unmyelinated nerve axons.   He died in 1963. Erlanger remained as Head of Physiology at Washington University until 1946.   He continued working on problems of peripheral nerve including excitation, effects of polarization and repetitive firing of axons.   In addition to research, he contributed much as an administrator and teacher.   A founding member of the Executive Faculty, he played a large role in the building of the modern Washington University School of Medicine.   He died in 1965.

 

Past Erlanger-Gasser Speakers

1990

Dr. Stanley Cohen

1991

Dr. George E. Palade

1992

Dr. Andrew Huxley

1992

Dr. Bert Sakmann

1994

Dr. Edwin G. Krebs, M.D.

1995

Dr. Gunter Blobel

1996

Dr. Alfred G. Gilman

1998

Dr. Gerald D. Fischbach

2000

Dr. Floyd E. Bloom

2002

Dr. Clay M. Armstrong

2003

Dr. Wolfhard Almers

2004

Dr. Anton J. Berns

2006

Dr. Thomas D. Pollard

 



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